解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::We investigated the clinical significance of the expression levels of matrix metalloproteinase 9 (MMP-9) in renal cell carcinoma (RCC). In addition, we validated the efficacy of pyrrole imidazole polyamide (PIP) targeting MMP-9 on inhibiting proliferation and invasion of RCC. We evaluated the expression levels of MMP-...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.2073
更新日期:2013-11-01 00:00:00
abstract::Although most hepatocellular carcinoma (HCC) is related to viral infection, there is a substantial population of HCC patients (5-20%) who are negative for both markers of hepatitis B virus and hepatitis C virus infection [non-B, non-C (NBNC) hepatitis] in Japan and the incidence of NBNC-HCC has recently tended to incr...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:10.3892/ijo.2013.2061
更新日期:2013-11-01 00:00:00
abstract::Angiogenesis plays a critical role in the development of solid tumors by supplying nutrients and oxygen to support continuous growth of tumor as well as providing an avenue for hematogenous metastasis. Tumor angiogenesis is highly regulated by multiple intracellular signaling transduction cascades such as Hedgehog, ST...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.2101
更新日期:2013-11-01 00:00:00
abstract::Telomerase has been recognized as a common factor in most tumor cells, and in turn a distinctive feature with respect to non-malignant cells. This feature has made telomerase a promising target for cancer therapy. Telomerase studies revealed that it is a multi-subunit complex possessing different levels of regulation,...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:10.3892/ijo.2013.2104
更新日期:2013-11-01 00:00:00
abstract::Choriocarcinoma is a highly malignant trophoblastic tumor related to pregnancy that often occurs with a complete hydatidiform mole. It grows quickly and can also widely metastasize to other organs or tissues through both the venous and lymphatic systems. The transforming growth factor-β1 (TGF-β1) belongs to a growth f...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.2026
更新日期:2013-10-01 00:00:00
abstract::Alternative polyadenylation and microRNA regulation are both mechanisms of post-transcriptional regulation of gene expression. Alternative polyadenylation often results in mRNA isoforms with the same coding sequence but different lengths of 3' UTRs, while microRNAs regulate gene expression by binding to specific mRNA ...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:10.3892/ijo.2013.2047
更新日期:2013-10-01 00:00:00
abstract::Seaweeds are commonly used as functional foods and drugs. A glycoprotein (GP) from the green alga Capsosiphon fulvescens (Cf) has been reported to have antitumor activity toward various cancer cells. We previously observed that Cf-GP induced different pathways of apoptosis in AGS human gastric cancer cells. Transformi...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.2055
更新日期:2013-10-01 00:00:00
abstract::The development of colorectal cancer (CRC) is strongly correlated with the aberrant activation of multiple intracellular signaling transduction cascades including STAT3, ERK, JNK and p38 pathways which usually function redundantly. In addition, crosstalk between these pathways forms a complicated signaling network tha...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.2040
更新日期:2013-10-01 00:00:00
abstract::Chronic exposure to nickel compounds is associated with increased incidence of certain types of human cancer, including lung and nasal cancers. Despite intensive investigation, the oncogenic processes remain poorly understood. Apoptosis resistance is a key feature for tumor cells to escape physiological surveillance a...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.2004
更新日期:2013-09-01 00:00:00
abstract::Progression of oral carcinomas associates with aberrant activation and inactivation of molecules that work in established or unknown pathways. Although mucosa‑associated lymphoid tissue 1 (MALT1) expressed in normal oral epithelium is inactivated in the aggressive subset of carcinomas with worse prognosis, phenotypic ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1990
更新日期:2013-09-01 00:00:00
abstract::The long-term survival for elderly patients with advanced ovarian papillary serous carcinoma (OPSC) does not exceed 30%, and the incidence and prognosis rise continuously after menopause. The aim of this study was to identify the differences in key miRNAs and their potential regulators through miRNA microarray analysi...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1988
更新日期:2013-09-01 00:00:00
abstract::The poor prognosis of Ewing's sarcoma (EWS), together with its high lethal recurrence rate and the side‑effects of current treatments, call for novel targeted therapies with greater curative effectiveness and substantially reduced side‑effects. The oncogenic chimeric protein EWS/FLI1 is the key malignancy driver in mo...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.2016
更新日期:2013-09-01 00:00:00
abstract::Experimental evidence indicates that prostate apoptosis response-4 (Par-4, also known as PAWR) is a key regulator of cancer cell survival and may be a target for cancer-selective targeted therapeutics. Par-4 was first identified in prostate cancer cells undergoing apoptosis. Both intracellular and extracellular Par-4 ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1983
更新日期:2013-08-01 00:00:00
abstract::New drugs that inhibit the osteoprotegerin (OPG)/receptor activator of NF-κB ligand (RANKL)/RANK pathway have demonstrated efficacy for the treatment of bone metastasis. Toxicities induced by these drugs, however, including osteonecrosis of the jaw and hypocalcemia, may adversely affect therapy. The aim of this study ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1954
更新日期:2013-08-01 00:00:00
abstract::Magnolol, a neolignan from the traditional medicinal plant Magnolia obovata, has been shown to possess neuroprotective, anti-inflammatory, anticancer and anti-angiogenic activities. However, the precise mechanism of the anti-angiogenic activity of magnolol remains to be elucidated. In the present study, the anti-angio...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1959
更新日期:2013-08-01 00:00:00
abstract::Oxidative stress due to intratumoral hypoxia in solid cancer has been shown to be associated with increased mortality. Phosphoglycerate kinase 1 (PGK1) is an enzyme of the glycolytic pathway, which is regulated by hypoxia-inducible factor-1α (HIF-1α) and has been described for its role in tumor progression and metasta...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1971
更新日期:2013-08-01 00:00:00
abstract::Galiximab is a primatized monoclonal antibody that targets CD80 expressed on malignant B cells and is being studied in the clinic as a potential treatment for follicular NHL. We have recently reported that galiximab signals B-NHL cells in vitro and inhibits cell growth and sensitizes resistant tumor cells to apoptosis...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1986
更新日期:2013-08-01 00:00:00
abstract::Quinazolinone derivatives are known to possess anticancer activities on cell metastasis and cell death in different human cancer cell lines. Here, we studied the anti-metastasis activity and the underlying mechanisms of the novel quinazoline derivative MJ-56 (6-pyrrolidinyl-2-(3-bromostyryl)quinazolin-4-one). MJ-56 in...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1941
更新日期:2013-07-01 00:00:00
abstract::It is well established that the tumor microenvironment plays a major role in the aggressive behavior of malignant solid tumors. Among cell types associated with tumor microenvironment, tumor-associated macrophages (TAMs) are the most influential for tumor progression. Breast cancer is characterized by having a large p...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:10.3892/ijo.2013.1938
更新日期:2013-07-01 00:00:00
abstract::Peyronie's disease (PD) is fibrosis localized in the tunica albuginea that is characterized by penile deformity and curvature. The pathogenesis of this disease remains unclear even though transforming growth factor-β (TGF-β)/smad signalling has been reported to be associated with PD. Recent studies have shown that pho...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1905
更新日期:2013-06-01 00:00:00
abstract::Normal cells produce energy either through OXPHOS in the presence of oxygen or glycolysis in its absence. Cancer cells produce energy preferably through glycolysis even in the presence of oxygen, thereby, acquiring survival and proliferative advantages. Oncogenes and tumour suppressors control these metabolic pathways...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1907
更新日期:2013-06-01 00:00:00
abstract::Double-stranded RNA-dependent protein kinase (PKR) is one of the players in the cellular antiviral responses and is involved in transcriptional stimulation through activation of NF-κB. Treatment of the human osteosarcoma cell line MG63 with the protein phosphatase inhibitor okadaic acid stimulated the expression and p...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1911
更新日期:2013-06-01 00:00:00
abstract::No population-based study has been conducted on the relationship between chemotherapy and the risk of cognitive impairments in patients with colorectal cancer. This study aimed to determine this association in a large population-based cohort of patients. We studied 72,374 men and women who were diagnosed with stages I...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1882
更新日期:2013-06-01 00:00:00
abstract::Breast cancer (BC) continues to affect the lives of millions of women worldwide. Several members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) subfamily are involved in tumor progression. Notably, the CEACAM subfamily harbors the already established cancer biomarker CEA, as well as other pote...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1860
更新日期:2013-05-01 00:00:00
abstract::It has been reported that suppression of selenium‑binding protein 1 (SBP1) occurs in many human malignancies which is considered to play an important role in cancer development and progression. Despite its importance in cancer, the function and factors that regulate its expression are not known. Using cell proliferati...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1850
更新日期:2013-05-01 00:00:00
abstract::Liquid crystals are the state of matter existing between liquid and crystalline phases, and recently there has been increasing interest in their biological effects. Following our recently reported work, we investigated the cell suppressive effects of liquid crystal-related compounds (LCRCs), which are precursors of li...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1804
更新日期:2013-04-01 00:00:00
abstract::Currently, some evidence suggests that human multipotential mesenchymal stems cells (hMSCs) aid tumor growth and metastasis. Nutrient deprivation and oxygen deficiency are representative characteristics of solid tumor microenvironment during the cancer development. Because the effects of hMSCs on tumors under stressfu...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1810
更新日期:2013-04-01 00:00:00
abstract::To overcome the poor tumor transduction efficiency of adenovirus serotype 5 (Ad5) observed in several types of cancer, the fiber region of Ad5, apart from its tail, was replaced by adenovirus serotype 35 (Ad35). The chimeric Ad5/F35 adenoviral vector did not exhibit any significant enhancement of transduction efficien...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1812
更新日期:2013-04-01 00:00:00
abstract::All p53 family members are expressed in several isoforms through alternative promoters and alternative splicing. However, the significance of these isoforms is not yet well understood in cholangiocarcinoma (CCA). In this study, we investigated the expression of p53, p63, p73 and their isoforms at the mRNA and protein ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1818
更新日期:2013-04-01 00:00:00
abstract::Chemokine (C-C motif) ligand 21 (CCL21) and SPARC-like protein 1 (SPARCL1/MAST9/hevin/SC-1) are associated with various biological behavior in the development of cancers. Although the expression of CCL21 and SPARCL1 is downregulated in many solid tumors, their roles in ovarian cancer and their associations with drug r...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1819
更新日期:2013-04-01 00:00:00
abstract::Dual oxidase 2 (Duox2), one of the seven members of the NADPH oxidase gene family, plays a critical role in generating H2O2 for thyroid hormone biosynthesis and as an integral part of the host defense system of the respiratory epithelium and the gastrointestinal tract. Recent evidence suggests that the regulation of D...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1821
更新日期:2013-04-01 00:00:00
abstract::Cancer stem cells (CSCs) are known to influence chemoresistance, survival, relapse and metastasis. Aldehyde dehydrogenase (ALDH) functions as an epithelial CSC marker. In the present study, we investigated the involvement of ALDH in gastric CSC maintenance, chemoresistance and survival. Following screening for eight c...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1837
更新日期:2013-04-01 00:00:00
abstract::Squamous cell carcinoma antigen (SCCA) is overexpressed in many squamous cell cancers and SCCA‑derived peptide-specific CD8(+) cytotoxic T lymphocytes can display cytotoxicity against tumor cells. In the present study, we screened the SCCA amino acid sequence for potential HLA-A*0201-binding CD8(+) T‑cell epitopes usi...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1834
更新日期:2013-04-01 00:00:00
abstract::Abnormal accumulation and activation of the recepteur d'origine nantais (RON) has been implicated in epithelial tumor carcinogenesis. In the present study, we examined the effect of epigallocatechin-3-gallate (EGCG), the major green tea catechin, on the induction of RON and tumor growth in human gastric cancer. EGCG i...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1775
更新日期:2013-03-01 00:00:00
abstract::The signal transducer and activator of transcription 3 (STAT3) factor plays an important role in the tumorigenicity of cancer stem cells. The purpose of this study was to investigate the inhibitory mechanism of this pathway acting through the tumor suppressor von Hippel-Lindau (VHL) protein in glioma cancer stem cells...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1773
更新日期:2013-03-01 00:00:00
abstract::The non-invasive treatment of tumors with preserved fertility holds great promise. The application of pulsed electric field (PEF) is a new biomedical engineering technique for tumor therapy. Picosecond pulsed electric fields (psPEF) can be transferred to target deep tissue non-invas...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1774
更新日期:2013-03-01 00:00:00
abstract::Baicalin is one of the major compounds in the traditional Chinese medicinal herb from Scutellaria baicalensis Georgi. We investigated the molecular mechanisms of cell autophagy induced by baicalin in human bladder cancer T24 cells. Baicalin inhibited cell survival as shown by MTT assay and increased cell death by tryp...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1791
更新日期:2013-03-01 00:00:00
abstract::Cordycepin is the main functional component of Cordyceps militaris, which has been widely used in oriental traditional medicine. This compound has been shown to possess many pharmacological properties, such as enhancing the body's immune function, and anti-inflammatory, anti-aging and anticancer effects. In the presen...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1762
更新日期:2013-03-01 00:00:00
abstract::An endocrine disrupting chemical (EDC) is a global health concern. In this study, we examined the effects of genistein (GEN) on bisphenol A (BPA) or 17β-estradiol (E2)-induced cell growth and gene alterations of BG-1 ovarian cancer cells expressing estrogen receptors (ERs). In an in...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1719
更新日期:2013-02-01 00:00:00
abstract::Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a major limitation for its clinical use. The mechanisms of TRAIL resistance have been mostly studied in the context of cell lines that are intrinsically resistant to TRAIL. However, little is known about the molecular alterations that con...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1748
更新日期:2013-02-01 00:00:00